Eric Guisbert

The Guisbert laboratory uses the nematode worm, Caenorhabditis elegans and cultured human cells to make new discoveries focused on regulation of a cell signaling pathway called the heat shock response.  The heat shock response is an essential stress response that is also involved in human diseases including cancer and Alzheimer's disease.  Our hope is that by learning more about the basic biology of this pathway we can contribute to a better understanding of these diseases and the development of new therapeutic strategies.
Dr. Eric Guisbert started his scientific career as an undergraduate researcher in the Cancer Research Department of Parke-Davis Pharmaceuticals where he did pre-clinical drug development in mouse cancer models.  For his PhD, he investigated regulation of a stress response pathway called the heat shock response in the laboratory of Carol Gross at the University of California, San Francisco.  He then switched to studying the eukaryotic heat shock response during his postdoctoral fellowship with Rick Morimoto at Northwestern University.   

Publications

  • Guisbert E, Morimoto RI. Regulation and Function of the Heat Shock Response. Protein Quality Control in Neurodegenerative Diseases. 2013. Springer. p 1-18.
  • Guisbert E, Yura T, Rhodius VA, Gross CA. Convergence of molecular, modeling and systems approaches for an understanding of the Escherichia coli heat shock response. Microbiol Mol Biol Rev. 2008 Sep:72(3):545-54.
  • Yura T*, Guisbert E*, Poritz M, Lu CZ, Campbell E, Gross CA. Analysis of sigma32 mutants defective in chaperone-mediated feedback control reveals unexpected complexity of the heat shock response. Proc Natl Acad Sci USA. 2007 Nov, 6;104(45):17638-43.
  • Guisbert E*, Rhodius V*, Ahuja N, Witkin E, Gross CA. Hfq modulates the sigmaE-mediated envelope stress response and the sigma32-mediated cytoplasmic stress response in E. coli. J. Bacteriol. 2007 Mar;189(5):1963-73.
  • Guisbert E, Herman C, Lu CZ, Gross CA. A chaperone network controls the heat shock response in E. coli. Genes Dev. 2004 Nov 15;18(22):2812-21.
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Article of the month

• Douglas P*, Baird N, Simic M, Wolff S, Kennedy B, Dillin A. Heterotypic Signals from Neural HSF-1 Separate Thermotolerance from Longevity. 
Cell Rep. 2015 August 18; 12(7): 1196–1204. doi:10.1016/j.celrep.2015.07.026.